The neuroscientist and the longevity physician. Between them they have probably shaped more supplement routines than anyone alive, and they are friends who appear on each other's podcasts. But their stacks are built for different jobs, and the differences are where it gets useful.
Same inputs, different jobs
Why the two most-copied stacks on the internet do not match.
Andrew Huberman's supplement list exists to serve his protocols: morning light, exercise, focus blocks, and above all sleep. That is why the most famous part of it is the sleep cocktail of magnesium threonate, theanine and apigenin he has described repeatedly on Huberman Lab. Almost everything he takes maps to something you can feel within a day or a week.
Peter Attia's list exists to serve a forty-year plan. As he lays out in Outlive, he treats supplements as a small tool next to exercise, protein and sleep, and he doses things like omega-3 against actual blood measurements. His stack has more magnesium variants than most people have supplements, because he cares about the total daily elemental dose, not the label.
BEYOND SUPPLEMENTS No stack adds muscle you did not earn. EMS might. Twenty minutes, twice a week, every major muscle group under load. Here is what the studies actually measured. READ THE RESEARCH →The stacks, category by category
What each takes, and the closest products you can buy.
The shared core
Both stacks agree on four things: AG1 as a base, vitamin D3, omega-3 fish oil and magnesium. Two very different frameworks, one nearly identical foundation. If you only copied the overlap, you would have most of the value of either protocol at a fraction of the effort.
Which protocol should you steal?
Pick by time horizon. If you want to feel a difference this month, Huberman's sleep and focus stack is the faster payoff. If you think in decades and like data, Attia's measure-first approach is the sturdier framework. And since they agree on the foundation, starting there is not really a compromise at all.
This is an independent editorial breakdown and is not affiliated with, endorsed by, or sponsored by the people or brands mentioned. Both figures discuss their own regimens publicly; the products here are our own picks based on what each has said and may not match their exact personal choices. Some links are affiliate links, which support our work at no extra cost to you. None of this is medical advice.
Frequently asked questions
What is the difference between Huberman's and Attia's supplements?
Huberman's stack is built around daily performance: sleep, focus and hormone support, with his well-known magnesium threonate, theanine and apigenin sleep cocktail. Attia's stack is built around longevity medicine: protein targets, omega-3 dosed to blood levels, several forms of magnesium and B vitamins chosen off lab work.
What do Huberman and Attia both take?
Both take AG1 as a base, vitamin D3, omega-3 fish oil and magnesium. The overlap is striking given they arrived from different directions, one from neuroscience and one from clinical medicine.
Does Peter Attia take creatine?
Attia has discussed creatine positively for muscle and brain and his protein-first approach pairs naturally with it, while Huberman includes creatine in his daily stack outright. If you train, it is one of the safest bets in either protocol.
Which protocol is better for me?
If your goals are sharper days, better sleep and training performance, Huberman's list is the more direct template. If your frame is decades-long healthspan and you like measuring before supplementing, Attia's approach fits better. The shared core of AG1, D3, omega-3 and magnesium works for both. None of this is medical advice.