One is a Harvard professor who studies why we age. The other is a tech founder spending millions a year trying not to. Their supplement stacks overlap less than you would think, and on one famous molecule they flatly disagree.
The scientist and the experiment
Two very different answers to the same question.
David Sinclair's stack reads like his research papers. NMN to raise NAD levels, resveratrol to activate sirtuins, quercetin and fisetin from the senolytics literature, TMG to support methylation. He describes the reasoning in Lifespan and on his podcast, and he is careful to frame it as personal experimentation rather than prescription. It is a bet that a handful of molecules his lab studies will pay off over decades.
Bryan Johnson's Blueprint protocol is the opposite temperament: measure roughly everything, supplement against the data, publish it all. Notably, his team reviewed resveratrol and cut it from the protocol, the same molecule Sinclair is most associated with. Watching where these two agree and disagree is one of the best free educations in how thin longevity evidence still is.
The stacks, category by category
What each takes, and the closest products you can buy.
Where the rivals agree
For all the disagreement, three things survive both filters: an NAD precursor, omega-3 fish oil and vitamin D3. If the two most famous names in longevity only agree on three supplements, that tells you how experimental everything else on both lists still is.
Whose bet would you rather make?
Copying Sinclair costs a few hundred dollars a month and rests on his own lab's science, which critics note is still contested. Copying Johnson in full is a job and a fortune, but his data-first process is exactly why his stack keeps shrinking as weak evidence gets cut. The honest play for most people: take the three they agree on, spend the rest on sleep, food and training, and watch how their experiment turns out.
This is an independent editorial breakdown and is not affiliated with, endorsed by, or sponsored by the people or brands mentioned. Both figures discuss their own regimens publicly; the products here are our own picks based on what each has said and may not match their exact personal choices. Some links are affiliate links, which support our work at no extra cost to you. None of this is medical advice.
Frequently asked questions
What is the difference between Sinclair's and Bryan Johnson's stacks?
Sinclair takes a targeted list of around a dozen items aimed at the aging pathways he researches, built around NMN and resveratrol. Johnson runs the maximalist Blueprint protocol with dozens of supplements, constant biomarker testing and his own product line.
Do Sinclair and Bryan Johnson disagree on resveratrol?
Yes, and it is the most interesting split in longevity. Sinclair still takes resveratrol daily with fat, based on his own sirtuin research. Johnson removed resveratrol from Blueprint, saying the human evidence did not hold up when his team reviewed it.
What do Sinclair and Bryan Johnson both take?
Both take an NAD precursor (NMN or NR), omega-3 fish oil and vitamin D3. That small overlap is notable given how differently the two approach everything else.
Whose longevity approach should I follow?
Neither stack is proven to extend human life, and both men say as much in their own ways. Sinclair's shorter list is cheaper to copy and Johnson's Blueprint is the most documented protocol alive, but the shared basics plus sleep, exercise and diet carry most of the known benefit. None of this is medical advice.