Two of the most followed men in self optimization, two very different philosophies. One is trying to measure and reverse aging to the decimal point. The other is translating neuroscience into protocols anyone can run. Here is how their supplement stacks actually compare, and what you can buy to build either one.
Two schools of optimization
Before the stacks, it helps to understand why these two get compared so often.
Bryan Johnson turned a fortune from selling Braintree and Venmo into the most public longevity experiment on the planet. His Blueprint protocol treats his body like a system to be measured, with dozens of supplements, a strict diet and constant biomarker testing, all published openly so anyone can copy or critique it. The pitch is simple and extreme: do everything the evidence supports, track the results, and try not to die.
Andrew Huberman comes at it from the lab. As a Stanford neuroscientist and host of the Huberman Lab podcast, he has spent years translating research on sleep, focus and hormones into protocols people can actually run, and he discusses his own stack openly on the show. Where Johnson optimizes for the single goal of longevity, Huberman optimizes for daily performance, and his list is far shorter and cheaper. Two honest, public approaches, which is exactly why comparing them is useful.
The protocols by the numbers
A rough side by side of how the two approaches differ in scale.
Read it one way and Johnson wins on sheer rigor: nobody publishes more data or tests more interventions. Read it the other way and Huberman wins on practicality, because almost anyone can afford and follow a ten item list. Neither is wrong. They are optimizing for different things, and the interesting part is how much their core stacks still overlap.
The stacks, category by category
What each man leans on, and the closest products you can buy to build the same habit.
What they actually share
Strip away the extremes and the two stacks agree on a surprising amount. Both take creatine, both take a high quality omega-3, both prioritize vitamin D, and both lean on magnesium for sleep and recovery. If you only ever copied the overlap, you would have most of what matters in either protocol.
Which protocol should you steal?
It depends on your budget and your goal. If you want the maximal, measure everything Johnson approach and can afford it, his published Blueprint is the most documented longevity stack alive. If you want something you can start this week for a reasonable cost, the Huberman list of a greens drink, creatine, omega-3, vitamin D and a simple sleep stack is the smarter place to begin. The honest answer for most people is to start with the shared core and add from there.
This is an independent editorial breakdown and is not affiliated with, endorsed by, or sponsored by the people or brands mentioned. Both figures publicly document their own protocols; the products here are our own picks based on what each has discussed publicly and may not match their exact personal choices. Some links are affiliate links, which support our work at no extra cost to you. None of this is medical advice.
Frequently asked questions
What is the difference between Bryan Johnson and Andrew Huberman's supplements?
Bryan Johnson runs a maximalist longevity stack of 50 to 100 plus supplements a day, published as his Blueprint protocol and driven by constant biomarker testing. Andrew Huberman runs a much shorter list of around 10 to 12 core supplements focused on daily focus, sleep and hormone support. They overlap on creatine, omega-3, vitamin D and magnesium.
What supplements do Bryan Johnson and Andrew Huberman both take?
Both take creatine, a high quality omega-3, vitamin D and magnesium. That shared core is the simplest, most evidence backed part of either protocol and the easiest place for most people to start.
Is Andrew Huberman's stack cheaper than Bryan Johnson's?
Yes, by a wide margin. Huberman's roughly ten item list is affordable for most people, while Johnson's Blueprint protocol involves dozens of interventions and a very high monthly cost. If budget matters, the Huberman approach is the more practical starting point.
Which supplement routine is better to follow?
It depends on your goal and budget. Johnson's Blueprint is the most documented longevity stack available if you want maximal effort. Huberman's shorter list is easier to start and sustain. For most people, beginning with the shared core of creatine, omega-3, vitamin D and magnesium and adding from there is the sensible path. None of this is medical advice.